What's OSDrC®

Manufacturing Process and Technical Characteristics of OSDrC® Tablets

One-Step Manufacture of Cored Tablets with Variable Double-Punch Technology

The OSDrC® rotary tableting machine, with its variable double-punch configuration, supports single-step manufacturing of pharmaceutical products. In addition to the commercial-scale production of conventional cored (tablet-within-a-tablet) tablets, this machine is ideal for manufacturing a variety of high-quality drug products at low cost.

A freely movable tablet punch with a variable double structure

The process of manufacturing core tablets in one step

Various Tablet Configurations Can be Produced Simply by Changing Punches

One-Step Process for Manufacturing Core Tablets

The types of tablet configurations that can be manufactured with OSDrC® are unlimited, depending only on the double-punch variations. OSDRrC technology lets formulators and process engineers freely control the appearance of the tablet and shape of the core, as well as giving them the ability to select the thickness of the coating and precisely control the core's position. This paves the way for completely new types of drug products, such as dividable cored tablets, that were not possible with existing technology.

A specialized device that enables innovative tablet manufacturing.

Complex Piston Motion by Cam Function

An innovative cam design is the key to the movement of the double punch system. This cam function allows complex and independent punch movements while maintaining comparable or better productivity than conventional tableting machines.
Additionally, features that prevent cross-contamination of powder between feeders, dust collection on the table surface, removal of residual powder, and recycling of excess powder significantly reduce risk and cost in manufacturing.
also comes equipped with several highly advanced functions conforming to Good Manufacturing Practice (GMP) standards, including a pressure monitor for each layer, automatic sampling, and an automatic exclusion mechanism.

Application of OSDrC® technology

OSDrC® Provides Controlled Release

Precise OSDrC® positioning technology enables product development scientists to control the release of the API by altering the thickness of the outer coating. The ability to precisely position multiple cores allows the creation of tablet products with a variety of pulsatile drug release profiles.

Replacement for Sugar- and Film-Coated Tablets

OSDrC® technology can also produce cored tablets with extremely thin coats in a one-step process. OSDrC® tablets can therefore replace sugar- and film-coated tablets, substantially reducing manufacturing stages and production costs.

Cored Tablets with Poorly Compressible Cores

OSDrC® technology, which does not require a separate manufacturing process for the core, can even use powders with poor compressibility as the core matrix. As it is possible to directly encase core pharmaceutical powders with the outer coating, these powders can be used in oral rapid disintegration tablets. By using pellets in the core instead of powders, drugs that normally must be formulated as capsules can be produced as tablets. This technology will totally revamp current drug formulation design and manufacturing processes.

Divided Core Tablets

OSDrC® technology also makes it possible to manufacture divided tablets with separate cores in a one-step operation, a feat not possible with current technology. For example, OSDrC® divided enteric tablets are among the world's first dividable enteric coated tablets. Because the core remains fully encased in the coating even when the tablet is divided, the intended release profile remains unaffected by dividing the tablet.

Core and Coat Shapes are also Variable

OSDrC® tablets do not have to be round. The shape of the core, coating thickness, and tablet configuration can be varied simply by changing the punches.

Oral Rapid Disintegration Tablets

OSDrC® OD tablets (Oral rapid Disintegration tablets) are the new concept tablet, which make it possible to design patient-friendly formulation. The API with poor compressibility can be contained in a tablet in high concentration and the tablet can be handled in the same way as conventional tablet because of good resistance to friability of the outer coating. Additionally, this technology adds functions such as taste masking and containment of high pharmacological APIs to the OD tablets.

What's OSDrC®

What's OSDrC®

One-Step Manufacture of Cored Tablets with Variable Double-Punch Technology

Various Tablet Configurations Can be Produced Simply by Changing Punches

A specialized device that enables innovative tablet manufacturing.

Application of OSDrC® technology

OSDrC® Provides Controlled Release

Replacement for Sugar- and Film-Coated Tablets

Cored Tablets with Poorly Compressible Cores

Divided Core Tablets

Core and Coat Shapes are also Variable

Oral Rapid Disintegration Tablets

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